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Module 05 · Electronic prescribing & controlled substances

One screen replaces the phone, the fax, and the eRx widget.

Surescripts to 95%+ of US pharmacies, real-time benefit cost, and DEA two-factor EPCS — with PDMP checks where state law requires them.

The signature mechanic

Every prescription runs the same gauntlet. Controlled ones hit a hard gate.

Compose, check interactions against the patient's global medication list, price it in real time, and — for Schedule II–V — clear the PDMP mandate and pass the DEA two-factor envelope before a single byte transmits. The EPCS gate is not a workflow preference; it's a hard stop.

Prescribe flow with DUR, real-time benefit, PDMP, and EPCS two-factor gate A horizontal prescribing flow: compose the order, run drug-utilization-review interaction checks against the global medication list, fetch real-time prescription benefit cost, then a controlled-substance gate that requires a PDMP query plus DEA two-factor EPCS signing (IAL2 identity proofing and AAL2 token) before transmitting to the pharmacy via NCPDP SCRIPT. COMPOSE from the A/P drug · dose · qty DUR CHECK vs. global med list DDI · allergy · dose RTPB $4.20 tier 1 · alt shown CONTROLLED-SUBSTANCE GATE — Schedule II–V PDMP query ✓ state mandate satisfied IAL2 proofed ✓ AAL2 •••••• 21 CFR 1311 Non-controlled scripts skip the gate. Controlled ones cannot — paper/fax for Schedule II–V is a violation, not a fallback. TRANSMIT NCPDP SCRIPT 2017071 · 99.5% The whole Surescripts transaction set lives here: NewRx RxRenewal RxChange CancelRx Med History RTPB ePA

Only DEA-registered prescribers with active Schedule authority can reach the transmit button on a controlled substance, and the medication-history feed means the DUR check sees fills from every pharmacy the patient uses — not just this practice's slice.

The problem

Phone, fax, and a loosely tethered widget is not a prescribing system.

Prescribers can't see fill history from other providers, can't check cost before choosing a drug, and call in Schedule II–V scripts because their EHR lacks EPCS — a regulatory exposure the SUPPORT Act made financially urgent. Pharmacies call back; patients get sticker shock at the counter.

The whole Surescripts transaction set, native

NewRx, RxRenewal, RxChange, CancelRx, Medication History, RTPB, and ePA — all NCPDP SCRIPT 2017071, all inside the chart. Pharmacist-initiated renewal requests land in the prescriber's inbasket for one-click approve, deny, or modify. A cancellation propagates to the pharmacy instantly, before the wrong fill happens.

A medication list no single EHR can match

On chart open, the Surescripts medication-history feed populates the active list with fill data from all participating pharmacies. And because rev.health spans every practice the patient visits, the drug-utilization review engine evaluates against a longitudinal medication and allergy record — not one practice's partial view.

Key capabilities

From routine refills to Schedule II — one workflow.

NewRx with DUR + RTPB

Select a drug; interaction, allergy, condition, and dose-range checks run in real time, the patient's benefit cost appears, and formulary alternatives surface — all before signing.

EPCS two-factor signing

DEA 21 CFR 1311 compliant: IAL2 identity proofing, AAL2 multi-factor authentication (hard or soft token), FIPS 140-2 digital signature. Every controlled Rx, every time.

PDMP with mandate enforcement

Where state law mandates a PDMP check, the query runs automatically, the fill history surfaces, and the Rx is blocked until the mandate is satisfied. State-by-state coverage through PMP gateway integrations.

Real-Time Prescription Benefit

Copay, tier, PA requirement, and cheaper on-formulary alternatives — patient-specific, at the point of prescribing. No more pharmacy-counter surprises.

Renewal & change inbasket

Pharmacy-initiated requests arrive as structured messages, route as tasks, and resolve with one click. Median turnaround target: two business hours.

CancelRx that actually cancels

Wrong drug, late-discovered allergy, duplicate therapy — the cancel reaches the pharmacy instantly and prevents the fill.

Medication history import

Surescripts MHX fills the active medication list on chart open and feeds medication reconciliation in the documentation flow.

ePA from the prescribing screen

Pharmacy-benefit prior auth initiated, tracked, and resolved inline through the Surescripts ePA network. No fax, no payer portal login.

Formulary alternatives

When the selected drug is non-preferred, on-formulary alternatives are suggested with the cost difference shown — a 30-second conversation instead of a next-day callback.

Workflow

A controlled-substance script, done right in 40 seconds.

Order from the A/P

The scribe proposed the medication; the prescriber confirms drug, dose, and duration from the encounter screen.

DUR + PDMP run automatically

The interaction check clears against the global med list; the state-mandated PDMP query completes and the fill history is one tap away.

Two-factor sign

Token plus credential inside the DEA envelope. Only DEA-registered prescribers with active Schedule authority can reach this button.

Transmitted — and tracked

First-attempt delivery target is 99.5%. The prescription status is visible to the care team and, through the portal, to the patient.

Who benefits

Prescriber (MD/DO)

DUR alerts, benefit cost, and formulary alternatives at the point of prescribing. One screen replaces phone, fax, and a separate eRx app.

PA / NP

Same flow with co-sign routing through Task Management where supervision requires it. EPCS identity proofing applies equally.

RN / MA

Works the renewal inbasket under standing orders; refill authorizations stop living in a paper tray.

Patient

Knows the drug costs $4.20 before leaving the room — and sees prescription status in the portal.

100% EPCS compliance is the target — every controlled-substance prescription signed through the two-factor envelope. Paper and fax Schedule II–V scripts are compliance violations, not workflows.

CheapRX integration · Phase 3 in development

The cheapest Rx, before it leaves the screen.

RTPB shows the insurance copay. CheapRX goes further — querying cash-price and discount-card databases across 70,000+ US pharmacies, then embedding the best coupon directly in the eRx. When the cash price beats the copay, the patient saves automatically. No separate app. No card to show at the counter.

Price comparison at prescribe time

Before you sign, CheapRX shows the insurance copay alongside the cheapest cash price at nearby pharmacies. If cash wins, the coupon is embedded in the eRx as a pharmacy note. Patient sees the savings in the portal.

One-click reorder

When a prescription is due for renewal, both patient and provider see a Reorder button. Provider click: renewal Rx sent to the same pharmacy with the original NDC, quantity, and CheapRX coupon. Patient click: renewal request sent to the provider's task queue. No refaxing, no phone tag.

Adherence tracking & smart nudges

Surescripts RxFill notifications tell us when a script is picked up. If a refill isn't filled within the day-supply window + 3-day grace, both patient and care team get a nudge. Catches the ~30% of scripts written but never filled, and the ~50% who abandon chronic meds within 6 months.

CheapRX is Phase 3 in development. RTPB and basic eRx ship in Phase 2. The full price-comparison, coupon-embedding, and adherence-tracking experience is shown in the demo and sales materials now so early design partners can evaluate the roadmap.

Performance targets

The numbers this module is built to hit.

MetricTarget
Prescriptions sent electronically≥ 98%
Controlled-substance Rx signed via EPCS100%
PDMP query compliance in mandated states100% — zero tolerance
RTPB coverage on new prescriptions≥ 90%
Renewal / change turnaround≤ 2 business hours median
ePA decision turnaround≤ 24 hours median
NewRx first-attempt delivery≥ 99.5%
DUR alert overrides≤ 15% DDI · ≤ 5% drug-allergy

Standards & the regulatory envelope

The network, the network's security, and the law around it.

NCPDP SCRIPT 2017071 Surescripts network (95%+ of US pharmacies) DEA EPCS — 21 CFR 1311 IAL2 / AAL2 identity & auth FIPS 140-2 digital signature RxNorm State PDMP / PMP gateway Surescripts RTPB & ePA

The SUPPORT Act made EPCS a Medicare requirement, and most states now mandate electronic controlled-substance prescribing — rev.health treats a paper or fax Schedule II–V script as a compliance violation rather than a workflow option.

Retire the fax line.

The full Surescripts network, EPCS, and PDMP — native to the chart.

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